Deficient antibody production may be either inherited or acquired:
• Inherited immunodeficiency is associated with rare genetic conditions and serious immune disorders. However, some patients with primary IgA deficiency (IgAD) are asymptomatic and are only identified after a laboratory result anomaly.
• Acquired immunodeficiency can occur as a result of an illness, especially those that cause a loss of protein in the body such as kidney disease or gastrointestinal disorders affecting protein absorption. Recurrent infections, chronic diarrhea, and the use of certain medications such as corticosteroids or immunosuppressants may also contribute to deficient antibody production.